Pramanik, Sreemanta and Surendran, Subin T and Saravana Devi, S and Krishnamurthi, Kannan and Chakrabarti, T (2014) Frequency and genotype distribution of ABCB1 gene polymorphisms among Maharashtrian population of Central India. Xenobiotica, 44 (6). pp. 579-582. ISSN 0049-8254 (Print) 1366-5928 (Electronic)

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1. Apart from conferring multidrug resistance to cancer cells, P-glycoprotein (P-gp) encoded by the gene ABCB1 (also, known as Multidrug resistance gene, MDR1), plays a major role in drug disposition. Single nucleotide polymorphisms (SNPs) in the ABCB1 gene might contribute to inter-individual and ethnic differences in drug disposition and thereby, could influence the outcome and prognosis of certain diseases. 2. India is one of the most ethnically and genetically diverse regions of the world. This study was undertaken with a view to determine the allele and genotype frequencies of C3435T and C1236T polymorphisms in the ABCB1 gene among the Maharshtrian population, residing in the Vidarbha region of central India and compare them with HapMap and other Indian populations. The common synonymous C3435T polymorphism has been found to be associated with lower P-gp functional expression and drug uptake, alone or in conjunction with a few other linked SNPs like C1236T. 3. The genotypes of C3435T and C1236T SNPs were determined by PCR-RFLP in 222 healthy and unrelated Maharashtrian individuals. 4. According to the findings of this study, the Maharashtrians were found to be not significantly different from the Gujarati Indians in Houston, Texas in the HapMap database.

Item Type: Article
Uncontrolled Keywords: Drug Disposition; HapMap; P-glycoprotein;SNP
Subjects: Environmental Health
Depositing User: Dr. Sreemanta Pramanik
Date Deposited: 01 Sep 2014 10:45
Last Modified: 08 May 2017 06:17

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