Daiwile, Atul P and Saravana Devi, S and Izzotti, Alberto and Bafana, Amit and Naoghare, Pravin K and Arrigo, Patrizio and Purohit, H J and Parmar, Devendra and Krishnamurthi, Kannan (2015) Noncoding RNAs: Possible Players in the Development of Fluorosis. BioMed Research International. ISSN 2314-6133
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Abstract
Fluorosis is caused by excess of fluoride intake over a long period of time. Aberrant change in the Runt-related transcription factor 2 (RUNX2) mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Up to date, role of fluoride on the epigenetic alterations is not studied. In the present study, global expression profiling of short noncoding RNAs, in particular miRNAs and snoRNAs, was carried out in sodium fluoride (NaF) treated human osteosarcoma (HOS) cells to understand their possible role in the development of fluorosis. qPCR and in silico hybridization revealed that miR-124 and miR-155 can be directly involved in the transcriptional regulation of Runt-related transcription factor 2 (RUNX2) and receptor activator of nuclear factor
| Item Type: | Article |
|---|---|
| Subjects: | Environmental Pollution Environmental Health |
| Divisions: | UNSPECIFIED |
| Depositing User: | Pravin Krishnarao Naoghare |
| Date Deposited: | 28 Apr 2016 05:57 |
| Last Modified: | 28 Apr 2016 05:57 |
| URI: | http://neeri.csircentral.net/id/eprint/568 |
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