Pramanik, Sreemanta and Surendran, Subin and Arumugam, Sathishkumar and Devi, Saravana and Krishnamurthi, Kannan and Chakrabarti, Tapan (2015) Polymorphisms in DNA repair and multidrug resistance genes among Sindhis of Central India. Environmental Toxicology and Pharmacology, 40. pp. 480-485. ISSN 1382-6689 (Print) and 1872-7077 (Online)

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Polymorphisms in DNA repair and multidrug resistance genes might contribute to interindividual and interethnic differences in DNA repair capacity and drug disposition respectively. In the present study, we determined the allele and genotype frequencies of four single nucleotide polymorphisms (SNPs) located in the DNA repair genes, XRCC1, XRCC3, XPD, OGG1, namely XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, and OGG1 Ser326Cys, respectively and two SNPs located in the multidrug resistance gene, ABCB1, namely ABCB1 C3435T and ABCB1 C1236T, in 33–35 healthy and unrelated Sindhi individuals, residing in the Vidarbha region of Central India and compared them with the Maharashtrian population from the same geographical region and some other HapMap populations from the HapMap database. The study findings reveal that the Indian Sindhis are closely related to the Maharashtrians as well as Utah residents with Northern and Western European ancestry and Gujarati Indians in Houston, Texas in the HapMap database.

Item Type: Article
Uncontrolled Keywords: DNA Repair; Multidrug Resistance; SNP; Cancer; Drug Disposition; Indian Sindhis
Subjects: Environmental Biotechnology
Environmental Health
Depositing User: Dr. Sreemanta Pramanik
Date Deposited: 19 Apr 2017 04:44
Last Modified: 19 Apr 2017 04:44

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