Devi, C. Shobha and Thulasiram, B. and Aerva, Rajeshwar Rao and Nagababu, Penumaka (2018) Recent Advances in Copper Intercalators as Anticancer Agents. Journal of Fluorescence, 28. pp. 1195-1205. ISSN 1053-0509, ESSN: 1573-4994

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Abstract

anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs. Herein, we briefly discuss the importance of reactive oxygen species in biological applications and copper(II) complexes as anticancer drugs. The anti-angiogenic properties of mono-nuclear copper(II) complexes have been demonstrated by in vivo chick embryo angiogenesis analysis. The plausible mechanism behind anticancer activity of these complexes is by the formation of excessive intracellular Reactive Oxygen Species (ROS). ROS is a composite term used for oxygen derivative non-radicals and free radicals of highly reactive components, that enhances the killing response of immune cells to microbial invasion. Previous reports have shown that ROS plays an important role as a messenger in cell cycling and normal cell signal transduction.

Item Type:	Article
Uncontrolled Keywords:	Copper; Cancer; DNA; ROS; Angiogenesis
Subjects:	Chemistry, Chemical Technology Materials Science
Divisions:	UNSPECIFIED
Depositing User:	Mr. RK Lohiya
Date Deposited:	25 Mar 2019 10:26
Last Modified:	25 Mar 2019 10:26
URI:	http://neeri.csircentral.net/id/eprint/1211

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